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rRNA Gene Transcription Initiation Complex - Molecular Mechanism #238263 (License: Personal Use)

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Diagram showing transcription initiation complex at rRNA gene promoter with UBF, SL1, PAF53, and Pol I binding upstream and core promoter elements.

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This schematic illustrates the stepwise assembly of the RNA Polymerase I (Pol I) pre-initiation complex on the ribosomal RNA (rRNA) gene promoter. Upstream Binding Factor (UBF) binds both the upstream promoter element (-186) and core promoter element (-50 to -31), facilitating recruitment of Selectivity Factor 1 (SL1) and the Pol I-PAF53 subcomplex near the transcription start site (+20). The diagram emphasizes spatial organization and protein-DNA interactions essential for ribosome biogenesis.
Used in molecular biology education, research presentations, and genomics resources to explain Pol I transcription regulation; targets students, researchers, and clinicians interested in gene expression or nucleolar function.
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Related Cliparts: Visual guide to eukaryotic rRNA transcription initiation: UBF, SL1, PAF53, and RNA Polymerase I assemble at upstream and core promoter elements (-186 to +20).

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