GPCR Signaling Pathway in Growth Hormone and Prolactin Regulation #1760974 (License: Personal Use)

The diagram details the canonical GPCR-mediated signaling cascade initiated by ligands like SCFAs, activating Gαs/Gαi subunits, adenylate cyclase (AC), and cAMP-dependent PKA. PKA phosphorylates CREB, which binds to cAMP response elements (CREs) on GH and PRL gene promoters alongside Pit-1, driving mRNA transcription and subsequent ribosomal synthesis of GH and PRL proteins. PTX inhibits Gi, while Ca²⁺ influx via channels modulates additional regulatory steps.

Used in endocrinology, molecular biology, or medical education web pages explaining pituitary hormone regulation; matches user intent for understanding signal transduction mechanisms behind GH/PRL secretion disorders or drug targets (e.g., somatostatin analogs).