DM3 Structure | Cytotoxic Payload in Antibody-Drug Conjugates (ADCs) #1530882 (License: Personal Use)

The image displays the detailed 2D chemical structure of DM3 (N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine), featuring a complex macrocyclic core with aromatic, aliphatic, and heterocyclic moieties, including a chlorinated methoxybenzene ring, multiple stereocenters, and a terminal thiol-containing linker. Key functional groups include amide bonds, ester linkages, hydroxyl, and methyl substituents that confer stability and binding affinity to tubulin. This structure enables DM3 to disrupt microtubule assembly, inducing apoptosis in targeted cancer cells.

This image is typically used on pharmaceutical R&D, oncology, or biotech webpages explaining ADC mechanisms, payload chemistry, or drug design. It serves researchers, clinicians, and students seeking structural insight into next-generation targeted cancer therapeutics.