p53 Protein Interaction Network Diagram - DNA Repair & Cancer Pathways #1951000 (License: Personal Use)

This scientific diagram illustrates a protein-protein interaction (PPI) network with tumor suppressor p53 as the central hub, surrounded by DNA damage response proteins (e.g., ATM/ATR substrates), ubiquitin ligases (e.g., MDM2, HUWE1), and repair complexes (e.g., RAD50-RAD23A-MSH2). Key nodes include SMC3, ML8, and PCNA, reflecting roles in chromatin remodeling, replication stress, and mismatch repair. Lines denote experimentally validated physical or functional interactions.

Used in molecular oncology, bioinformatics, and cancer research webpages to explain p53’s regulatory role; ideal for educational content, review articles, or interactive pathway tools targeting researchers and students.