FISH Imaging of Chromosomal Abnormalities in Cancer Diagnostics #1374236 (License: Personal Use)

This composite image displays fluorescence in situ hybridization (FISH) results across three stages: interphase nuclei with dispersed probe signals, split red/green signals suggesting chromosomal breakage, and metaphase spreads where translocated chromosomes confirm the BCR-ABL1 fusion-hallmark of chronic myeloid leukemia. Probes target specific loci (e.g., BCR in green, ABL1 in red, centromere in orange), enabling precise detection of structural variants at submicroscopic resolution.

Used in clinical cytogenetics labs and oncology diagnostics to identify gene fusions, deletions, or amplifications in hematologic malignancies and solid tumors; supports molecular pathology reports and guides tyrosine kinase inhibitor therapy decisions.