Enzyme-Substrate Complex: 2'-Fucosyllactose and UDP-Gal Binding in Fucosyltransferase #1404195 (License: Personal Use)

This high-resolution structural model depicts the binding of 2'-fucosyllactose and UDP-Gal to a human fucosyltransferase enzyme, revealing precise atomic interactions that drive human milk oligosaccharide (HMO) synthesis. Key catalytic residues-including W218, H122, N95, and D191-form hydrogen bonds and hydrophobic contacts with substrates, stabilizing the transition state. The image highlights the enzyme’s specificity for α-1,2-fucosylation, crucial for prebiotic and immunomodulatory functions in infant nutrition.

Used in academic publications, biotech product documentation, and educational resources on glycobiology or infant nutrition; targets researchers, students, and industry professionals seeking mechanistic insight into HMO biosynthesis enzymes.